NPC1L1
NPC1-like 1
别名:
NPC11L1
物种:
Human NPC1L1 (29881), Mouse Npc1l1 (237636), Rat Npc1l1 (432367), cow NPC1L1 (539550), naked mole-rat Npc1l1 (101718169), domestic guinea pig Npc1l1 (100716804), Domestic Rabbit NPC1L1 (100009042), sheep NPC1L1 (101118355), dog NPC1L1 (610398), domestic cat NPC1L1 (101099108)
UniProtKB ID:
基因ID:
- Human(29881) Summary: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Mouse(237636) NPC1-like 1
- Rat(432367) NPC1-like 1
- cow(539550) NPC1-like 1
- naked mole-rat(101718169) NPC1-like 1
- domestic guinea pig(100716804) NPC1-like 1
- Domestic Rabbit(100009042) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- sheep(101118355) NPC1-like 1
- dog(610398) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- domestic cat(101099108) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- Zebrafish(100616532) NPC1 (Niemann-Pick disease, type C1, gene)-like 1
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Antibodies
货号
说明
物种反应性
应用
ANTI-NPC1L1(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human
应用
western blot