LIMK1
LIM domain kinase 1
别名:
LIMK, LIMK-1
物种:
Human LIMK1 (3984), Mouse Limk1 (16885), Rat Limk1 (65172), domestic cat LIMK1 (101097861), Domestic Rabbit LIMK1 (100344018), dog LIMK1 (489800), Horse LIMK1 (100062100), naked mole-rat Limk1 (101698555), domestic guinea pig Limk1 (100712921), chicken LIMK1 (373922) ...展开
UniProtKB ID:
基因ID:
- Human(3984) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
- Mouse(16885) LIM-domain containing, protein kinase
- Rat(65172) LIM domain kinase 1
- domestic cat(101097861) LIM domain kinase 1
- Domestic Rabbit(100344018) LIM domain kinase 1
- dog(489800) LIM domain kinase 1
- Horse(100062100) LIM domain kinase 1
- naked mole-rat(101698555) LIM domain kinase 1
- domestic guinea pig(100712921) LIM domain kinase 1
- chicken(373922) LIM domain kinase 1
- fruit fly(32207) LIM-kinase1
- sheep(101110900) LIM domain kinase 1
- cow(535225) LIM domain kinase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LIMK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab2,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
ANTI-LIMK1 antibody produced in mouse, clone 2E9, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-LIMK1-T508/LIMK2-T505 antibody produced in rabbit, ,
物种反应性
human
应用
western blot
Proteins
货号
说明
物种
LIM Kinase 1 Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638, for use in Kinase Assays.,
物种
human
LIM Kinase 1 Protein, inactive, 50 g, Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.,
物种
human
esiRNA
货号
说明
物种