DUOXA1
dual oxidase maturation factor 1
别名:
NIP, NUMBIP, mol
物种:
Human DUOXA1 (90527), Mouse Duoxa1 (213696), Rat Duoxa1 (311374), dog DUOXA1 (487536), naked mole-rat Duoxa1 (101698524), domestic cat DUOXA1 (101086977), domestic guinea pig Duoxa1 (100734075), chicken DUOXA1 (427484), cow DUOXA1 (530151), sheep DUOXA1 (101115034)
UniProtKB ID:
基因ID:
- Human(90527) Summary: Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
- Mouse(213696) dual oxidase maturation factor 1
- Rat(311374) dual oxidase maturation factor 1
- dog(487536) dual oxidase maturation factor 1
- naked mole-rat(101698524) dual oxidase maturation factor 1
- domestic cat(101086977) dual oxidase maturation factor 1
- domestic guinea pig(100734075) dual oxidase maturation factor 1
- chicken(427484) dual oxidase maturation factor 1
- cow(530151) dual oxidase maturation factor 1
- sheep(101115034) dual oxidase maturation factor 1
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Antibodies
货号
说明
物种反应性
应用
Anti-NIP antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-DUOXA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry