CXCR2
chemokine (C-X-C motif) receptor 2
别名:
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
物种:
Human CXCR2 (3579), Mouse Cxcr2 (12765), Rat Cxcr2 (29385), cow CXCR2 (782719), sheep CXCR2 (101110214), naked mole-rat Cxcr2 (101712581), domestic cat CXCR2 (101085396), dog CXCR2 (478905), chicken CXCR2 (430652), Domestic Rabbit CXCR2 (100328627) ...展开
UniProtKB ID:
基因ID:
- Human(3579) Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
- Mouse(12765) chemokine (C-X-C motif) receptor 2
- Rat(29385) chemokine (C-X-C motif) receptor 2
- cow(782719) chemokine (C-X-C motif) receptor 2
- sheep(101110214) chemokine (C-X-C motif) receptor 2
- naked mole-rat(101712581) chemokine (C-X-C motif) receptor 2
- domestic cat(101085396) chemokine (C-X-C motif) receptor 2
- dog(478905) interleukin 8 receptor, beta
- chicken(430652) chemokine (C-X-C motif) receptor 2
- Domestic Rabbit(100328627) chemokine (C-X-C motif) receptor 2
- cow(281863) interleukin 8 receptor, beta
- domestic guinea pig(100379569) chemokine (C-X-C motif) receptor 2
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Antibodies
货号
说明
物种反应性
应用
Anti-CXCR2/IL-8RB Antibody, clone 2D18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, monkey
应用
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
抗-CXCR2 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-phospho-IL-8R β/CDw128 β (pSer347) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-CXCR2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-IL-8R β antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
ELISA
immunofluorescence
immunofluorescence