COCH
cochlin
别名:
COCH-5B2, COCH5B2, DFNA9
物种:
Human COCH (1690), Mouse Coch (12810), Rat Coch (362735), Zebrafish coch (368851), naked mole-rat Coch (101702852), dog COCH (490640), domestic cat COCH (101081053), Horse COCH (100055742), cow COCH (504316), Domestic Rabbit COCH (100351943) ...展开
UniProtKB ID:
基因ID:
- Human(1690) Summary: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
- Mouse(12810) coagulation factor C homolog (Limulus polyphemus)
- Rat(362735) cochlin
- Zebrafish(368851) coagulation factor C homolog, cochlin (Limulus polyphemus)
- naked mole-rat(101702852) cochlin
- dog(490640) coagulation factor C homolog, cochlin (Limulus polyphemus)
- domestic cat(101081053) coagulation factor C homolog, cochlin (Limulus polyphemus)
- Horse(100055742) coagulation factor C homolog, cochlin (Limulus polyphemus)
- cow(504316) coagulation factor C homolog, cochlin (Limulus polyphemus)
- Domestic Rabbit(100351943) coagulation factor C homolog, cochlin (Limulus polyphemus)
- sheep(101102269) coagulation factor C homolog, cochlin (Limulus polyphemus)
- chicken(395779) coagulation factor C homolog, cochlin (Limulus polyphemus)
- domestic guinea pig(100174920) coagulation factor C homolog (Limulus polyphemus)
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Antibodies
货号
说明
物种反应性
应用
抗-Cochlin抗体/COCH，克隆9A10D2, clone 9A10D2, from rat,
物种反应性
human, mouse
应用
immunohistochemistry
western blot
western blot
Anti-COCH antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-COCH antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
应用
western blot