BARD1
BRCA1 associated RING domain 1
别名:
物种:
Human BARD1 (580), Mouse Bard1 (12021), Rat Bard1 (64557), Thale Cress BARD1 (839329), naked mole-rat Bard1 (101722439), domestic guinea pig Bard1 (100731860), sheep BARD1 (101108373), Horse BARD1 (100053962), cow BARD1 (530961), dog BARD1 (610190) ...展开
UniProtKB ID:
基因ID:
- Human(580) Summary: This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008]
- Mouse(12021) BRCA1 associated RING domain 1
- Rat(64557) BRCA1 associated RING domain 1
- Thale Cress(839329) BRCA1-associated RING domain protein 1
- naked mole-rat(101722439) BRCA1 associated RING domain 1
- domestic guinea pig(100731860) BRCA1 associated RING domain 1
- sheep(101108373) BRCA1 associated RING domain 1
- Horse(100053962) BRCA1 associated RING domain 1
- cow(530961) BRCA1 associated RING domain 1
- dog(610190) BRCA1 associated RING domain 1
- domestic cat(101080728) BRCA1 associated RING domain 1
- chicken(424010) BRCA1 associated RING domain 1
- Zebrafish(333951) BRCA1 associated RING domain 1
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Antibodies
货号
说明
物种反应性
应用
Rabbit anti-BARD1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
物种反应性
human
应用
immunoprecipitation (IP)
western blot
western blot
Anti-BARD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-BARD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence