ADD2
adducin 2 (beta)
别名:
ADDB
物种:
Human ADD2 (119), Mouse Add2 (11519), Rat Add2 (24171), cow ADD2 (518896), domestic guinea pig Add2 (100724293), Horse ADD2 (100050348), domestic cat ADD2 (101097803), Zebrafish add2 (570147), dog ADD2 (610670), Domestic Rabbit ADD2 (100348972) ...展开
UniProtKB ID:
基因ID:
- Human(119) Summary: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
- Mouse(11519) adducin 2 (beta)
- Rat(24171) adducin 2 (beta)
- cow(518896) adducin 2 (beta)
- domestic guinea pig(100724293) adducin 2 (beta)
- Horse(100050348) adducin 2 (beta)
- domestic cat(101097803) adducin 2 (beta)
- Zebrafish(570147) adducin 2 (beta)
- dog(610670) adducin 2 (beta)
- Domestic Rabbit(100348972) adducin 2 (beta)
- sheep(101106757) adducin 2 (beta)
- naked mole-rat(101722886) adducin 2 (beta)
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Antibodies
货号
说明
物种反应性
应用
Anti-ADD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-ADD2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-ADD2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-ADD2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-ADD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry