ACO1
aconitase 1, soluble
别名:
ACONS, IREB1, IREBP, IREBP1, IRP1
物种:
Human ACO1 (48), Mouse Aco1 (11428), Rat Aco1 (50655), domestic cat ACO1 (101095526), Thale Cress ACO1 (816478), dog ACO1 (481576), sheep ACO1 (101112791), cow ACO1 (512995), Zebrafish aco1 (568448), Thale Cress ACO1 (829737) ...展开
UniProtKB ID:
基因ID:
- Human(48) Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- Mouse(11428) aconitase 1
- Rat(50655) aconitase 1, soluble
- domestic cat(101095526) aconitase 1, soluble
- Thale Cress(816478) 1-aminocyclopropane-1-carboxylate oxidase 1
- dog(481576) aconitase 1, soluble
- sheep(101112791) aconitase 1, soluble
- cow(512995) aconitase 1, soluble
- Zebrafish(568448) aconitase 1, soluble
- Thale Cress(829737) aconitate hydratase 1
- Horse(100067866) aconitase 1, soluble
- chicken(373916) aconitase 1, soluble
- naked mole-rat(101716545) aconitase 1, soluble
- domestic guinea pig(100720793) aconitase 1, soluble
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Antibodies
货号
说明
物种反应性
应用
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Iron Pegulatory Protein 1 Antibody, Chemicon®, from rabbit,
物种反应性
rat
应用
ELISA
western blot
western blot
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-ACO1 antibody produced in mouse, clone 2C1, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-ACO1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, human, pig, rat
应用
immunohistochemistry
western blot
western blot