- Contributions of caspase-8 and -9 to liver injury from CYP2E1-produced metabolites of halogenated hydrocarbons.
Contributions of caspase-8 and -9 to liver injury from CYP2E1-produced metabolites of halogenated hydrocarbons.
Xenobiotica; the fate of foreign compounds in biological systems (2017-01-14)
Yoshio Ijiri, Ryuji Kato, Maiko Sadamatsu, Mina Takano, Yuki Yasuda, Fumiaki Tanaka, Chiyo Oishi, Hideki Imano, Yoshikatsu Okada, Kazuhiko Tanaka, Tetsuya Hayashi
PMID28081667
摘要
1. Drug-induced liver injury is difficult to predict at the pre-clinical stage. This study aimed to clarify the roles of caspase-8 and -9 in CYP2E1 metabolite-induced liver injury in both rats and cell cultures in vitro treated with carbon tetrachloride (CCl
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