- Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.
Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.
Acta pharmacologica Sinica (2017-08-05)
Fan Wang, Ming-Xing Miao, Bin-Bin Sun, Zhong-Jian Wang, Xian-Ge Tang, Yang Chen, Kai-Jing Zhao, Xiao-Dong Liu, Li Liu
PMID28770824
摘要
HIV infection is often associated with liver failure, which alters the pharmacokinetics of many drugs. In this study we investigated whether acute liver failure (ALF) altered the pharmacokinetics of the first-line anti-HIV agent zidovudine (AZT), a P-gp/BCRP substrate, in rats. ALF was induced in rats by injecting thioacetamide (TAA, 300 mg·kg
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