Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.

Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen.

Biochemical and biophysical research communications (2017-01-21)

Mahendra Pratap Singh, Ki Young Kim, Hwa-Young Kim

摘要

Acetaminophen (APAP) overdose induces acute liver injury via enhanced oxidative stress and glutathione (GSH) depletion. Methionine sulfoxide reductase A (MsrA) acts as a reactive oxygen species scavenger by catalyzing the cyclic reduction of methionine-S-sulfoxide. Herein, we investigated the protective role of MsrA against APAP-induced liver damage using MsrA gene-deleted mice (MsrA