- The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer.
The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer.
Oncotarget (2017-10-21)
Valentina Mele, Lena Sokol, Viktor Hendrik Kölzer, Dennis Pfaff, Manuele Giuseppe Muraro, Irene Keller, Zahnd Stefan, Irene Centeno, Luigi Maria Terracciano, Heather Dawson, Inti Zlobec, Giandomenica Iezzi, Alessandro Lugli
PMID29050306
摘要
In colorectal cancer (CRC), RHAMM is an independent adverse prognostic factor. The aim of the study was therefore to investigate on the role of RHAMM as a potential direct driver of cell proliferation and migration in CRC cell lines and to identify pathways dependent on RHAMM in human CRC. Proliferation, cell cycle alterations and invasive capacity were tested in two RHAMM- and control- knockdown CRC cell lines by flow cytometry and
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