First universal pharmacophore model for hERG1 K

First universal pharmacophore model for hERG1 K

Journal of molecular graphics & modelling (2017-05-13)

Serdar Durdagi, Ismail Erol, Ramin Ekhteiari Salmas, Matthew Patterson, Sergei Y Noskov

摘要

The intra-cavitary drug blockade of hERG1 channel has been extensively studied, both experimentally and theoretically. Structurally diverse ligands inadvertently block the hERG1 K