- Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces.
Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces.
Biochimie (2017-05-10)
Sara La Manna, Pasqualina Liana Scognamiglio, Concetta Di Natale, Marilisa Leone, Flavia Anna Mercurio, Anna Maria Malfitano, Francesca Cianfarani, Stefania Madonna, Sergio Caravella, Cristina Albanesi, Ettore Novellino, Daniela Marasco
PMID28479106
摘要
Interleukin-22 (IL-22) belongs to the family of IL-10 cytokines and is involved in a wide number of human diseases, including inflammatory disorders and cancer pathology. The ligand-receptor complex IL-22/IL-22R plays a key role in several pathways especially in the regulation and resolution of immune responses. The identification of novel compounds able to modulate IL-22/IL-22R complex could open the route to new therapeutic strategies in multiple human diseases. In this study, we designed and characterized IL-22 derived peptides at protein interface regions: several sequences revealed able to interfere with the protein complex with IC
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