- Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.
Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.
Cell death & disease (2017-05-26)
H Dong, Y Zhang, J Wang, D S Kim, H Wu, B Sjögren, W Gao, L Luttrell, H Wang
PMID28542139
摘要
Pancreatic β-cell death and dysfunction contributes to the pathogenesis of both type 1 and type 2 diabetes. We aimed to examine whether the regulator of G protein signaling protein 2 (RGS2), a multifunctional inhibitor of G protein-coupled receptor (GPCR) signaling, impacts β-cell death and function. Metabolic phenotypes, β-cell secretory function, and glucose and insulin tolerance were measured in RGS2 knockout (RGS2