- Synthesis of Nanogel-Protein Conjugates.
Synthesis of Nanogel-Protein Conjugates.
Polymer chemistry (2014-04-25)
Nicholas M Matsumoto, Daniella C González-Toro, Reuben T Chacko, Heather D Maynard, S Thayumanavan
PMID24761162
摘要
The covalent conjugation of bovine serum albumin (BSA) to disulfide cross-linked polymeric nanogels is reported. Polymeric nanogel precursors were synthesized via a reversible addition-fragmentation chain transfer (RAFT) random copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGMA) and pyridyl disulfide methacrylate (PDSMA). Reaction of the p(PEGMA-