- Alterations in erythrocyte fatty acid composition in preclinical Alzheimer's disease.
Alterations in erythrocyte fatty acid composition in preclinical Alzheimer's disease.
Scientific reports (2017-04-08)
Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R Sohrabi, Prita R Asih, Preeti Dave, Bethany Ball, Candice ManYan, Kevin Taddei, Roger Chung, Manohar L Garg, Ralph N Martins
PMID28386119
摘要
Brain and blood fatty acids (FA) are altered in Alzheimer's disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65-90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand
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