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CN

JARID1B is a luminal lineage-driving oncogene in breast cancer.

Cancer cell (2014-06-18)
Shoji Yamamoto, Zhenhua Wu, Hege G Russnes, Shinji Takagi, Guillermo Peluffo, Charles Vaske, Xi Zhao, Hans Kristian Moen Vollan, Reo Maruyama, Muhammad B Ekram, Hanfei Sun, Jee Hyun Kim, Kristopher Carver, Mattia Zucca, Jianxing Feng, Vanessa Almendro, Marina Bessarabova, Oscar M Rueda, Yuri Nikolsky, Carlos Caldas, X Shirley Liu, Kornelia Polyak
摘要

Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their functional relevance is largely unknown. Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast cancer results in the gain of unique chromatin binding and luminal expression and splicing patterns. Downregulation of JARID1B in luminal cells induces basal genes expression and growth arrest, which is rescued by TGFβ pathway inhibitors. Integrated JARID1B chromatin binding, H3K4 methylation, and expression profiles suggest a key function for JARID1B in luminal cell-specific expression programs. High luminal JARID1B activity is associated with poor outcome in patients with hormone receptor-positive breast tumors.

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Sigma-Aldrich
抗二甲基组蛋白H3(Lys4)抗体, Upstate®, from rabbit
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货号包装规格是否有货价格数量
100 mg
预计发货时间 2025年4月14日
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¥2,672.55
500 mg
预计发货时间 2025年4月14日
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Sigma-Aldrich
抗-KDM5B 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 mg
预计发货时间 2025年4月14日
详情...
¥2,672.55
500 mg
预计发货时间 2025年4月14日
详情...
¥9,224.47