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Merck
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  • Diastereocontrolled synthesis of enantioenriched 3,4-disubstituted beta-prolines.

Diastereocontrolled synthesis of enantioenriched 3,4-disubstituted beta-prolines.

The Journal of organic chemistry (2007-01-16)
Fabrice Denes, Alejandro Perez-Luna, Fabrice Chemla
摘要

Enantioenriched 3,4-disubstituted beta-prolines have been prepared with a high diastereocontrol through a carbometalation reaction or through a domino Michael addition/carbometalation reaction.

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Sigma-Aldrich
(S)-吡咯烷-3-羧酸, ≥98.0% (NT)