Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.

Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.

Organic letters (2003-01-17)

Wenjun Tang, Duan Liu, Xumu Zhang

摘要

[reaction: see text] The Rh-TangPhos catalyst has been used for asymmetric hydrogenation of itaconic acid and enol acetate derivatives. A variety of chiral 2-substituted succinic acids and chiral acetates have been obtained in excellent ee values (up to 99% ee).