Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination.

Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination.

Journal of the American Chemical Society (2013-04-20)

Adam R Brown, Christopher Uyeda, Carolyn A Brotherton, Eric N Jacobsen

摘要

Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.