PSA and PAP as immunohistochemical markers in prostate cancer.

This article describes the immunoreactivity of PSA and PAP in non-neoplastic and neoplastic prostate tissue. Listed are examples of cross reactivity of PSA and PAP in non-neoplastic and neoplastic tissue from other organs. The use of PSA and PAP to identify tumors of prostatic origin in different sites is also described. Finally, the diagnostic uses of immunohistochemistry for PSA and PAP in prostate biopsies and for prognostication are discussed.