Endothelin inhibits renin release from isolated rat glomeruli.

Endothelin inhibits renin release from isolated rat glomeruli.

Biochemical and biophysical research communications (1988-09-30)

H Rakugi, M Nakamaru, H Saito, J Higaki, T Ogihara

摘要

The effect of endothelin on renin release from isolated rat glomeruli was examined. Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M). Nifedipine (10(-5) M), a calcium channel blocker, induced an increase in renin release. Endothelin did not affect this nifedipine-induced renin release. These results suggest that endothelin inhibits renin release via a calcium entry mechanism and increases intracellular calcium.