Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Science (New York, N.Y.) (1966-03-25)

M B Sporn, C W Dingman, H L Phelps, G N Wogan

摘要

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

材料

货号

品牌

产品描述

34029

Supelco

黄曲霉素 B₁ 溶液, 2 μg/mL in acetonitrile, analytical standard