- Xenon for NMR biosensing--inert but alert.
Xenon for NMR biosensing--inert but alert.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) (2011-11-29)
Leif Schröder
PMID22119272
摘要
NMR studies with hyperpolarized xenon as functionalized sensor or contrast agent recently made notable progress in developing a new approach for detecting molecular markers and parameters of biomedical interest. Combining spin polarization enhancement with novel indirect detection schemes easily enables a 10⁷-fold signal gain, thus having promising potential to solve the NMR sensitivity problem in many applications. Though an inert element, ¹²⁹Xe has exquisite NMR properties to sense molecular environments. This review summarizes recent developments in the production of hyperpolarized xenon and the design and detection schemes of xenon biosensors.