Aryl sulfones: a new class of gamma-secretase inhibitors.

Aryl sulfones: a new class of gamma-secretase inhibitors.

Bioorganic & medicinal chemistry letters (2005-05-03)

Martin Teall, Paul Oakley, Timothy Harrison, Duncan Shaw, Euan Kay, Jason Elliott, Ute Gerhard, José L Castro, Mark Shearman, Richard G Ball, Nancy N Tsou

PMID15863342

摘要

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.