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  • Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain.

Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain.

Cytogenetic and genome research (2002-11-20)
M Jiang, Y Ma, X Ni, G Cao, C Ji, H Cheng, R Tang, Y Xie, Y Mao
摘要

Leucine-rich acidic nuclear protein (LANP) is a member of the leucine-rich repeats (LRRs) superfamily. Here we report on a human homologue of LANP, encoded by the gene ANP32E (alias LANPL). The gene was cloned and identified during large-scale sequencing analysis of a human fetal brain cDNA library. The human protein shared 70% amino acid identity with rat LANP. According to bioinformatics analysis, ANP32E is located on chromosome 1q22. RT-PCR analysis indicates that ANP32E was expressed in human peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.