- The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
Cancer letters (2011-12-14)
Paulisally Hau Yi Lo, Josephine Mun Yee Ko, Zhuo You Yu, Simon Law, Li Dong Wang, Ji-Lin Li, Gopesh Srivastava, Sai Wah Tsao, Eric J Stanbridge, Maria Li Lung
PMID22154084
摘要
The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. Subcellular fractionation studies show that CRIP2 is expressed in the nucleus. Real-time quantitative PCR shows CRIP2 expression is down-regulated in ESCC tissues and cell lines. Functional studies reveal that CRIP2 reduces colony formation, growth, and invasion abilities. Furthermore, over-expression of CRIP2 induces apoptosis through induction of active caspases 3 and 9 proteins. In conclusion, this study shows CRIP2 plays an important role in the development of ESCC.
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