跳转至内容
Merck
CN
  • Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology.

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology.

Current medicinal chemistry (2004-07-29)
S Walenta, T Schroeder, W Mueller-Klieser
摘要

A number of studies have demonstrated that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagnosis of the disease, we showed that lactate concentrations in tumors in vivo could be relatively low or extremely high (up to 40 micromol/g) in different individual tumors or within the same lesion. In all tumor entities investigated, high molar concentrations of lactate were correlated with a high incidence of distant metastasis already in an early stage of the disease. Low lactate tumors (< median of approx. 8 micromol/g) were associated with both a longer overall and disease free survival compared to high lactate lesions (lactate > approx. 8 micromol/g). Lactate dehydrogenase was found to be upregulated in most of these tumors compared to surrounding normal tissue. Numerous recent reports support these data by demonstrating various biological activities of lactate that can enhance the malignant behavior of cancer cells. These mechanisms include the activation of hyaluronan synthesis by tumor-associated fibroblasts, upregulation of VEGF and of HIF-1 alpha, and direct enhancement of cellular motility which generates favorable conditions for metastatic spread. Thus, lactate accumulation not only mirrors but also actively enhances the degree of tumor malignancy. We propose that determination of lactate in primary tumors may serve as a basis for a novel metabolic classification which can lead to an improvement of prognosis and therapy in clinical oncology.

材料
货号
品牌
产品描述

Sigma-Aldrich
L-(+)-乳酸, ≥98%
登录查看公司和协议定价
货号包装规格是否有货价格数量
10 g
预计发货时间 2025年3月03日
详情...
¥1,640.66
100 g
预计发货时间 2025年3月03日
详情...
¥7,443.95
Sigma-Aldrich
L-(+)-乳酸, BioXtra, ≥98% (titration)
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 g
预计发货时间 2025年3月06日
详情...
¥735.29
5 g
预计发货时间 2025年3月11日
详情...
¥2,139.94
10 g
有货
详情...
¥3,694.57
Sigma-Aldrich
L-(+)-乳酸 溶液, in H2O, ≥85%
登录查看公司和协议定价
货号包装规格是否有货价格数量
250 g
预计发货时间 2025年3月03日
详情...
¥650.02
1 kg
请联系客服了解存货情况
¥2,011.90
Sigma-Aldrich
L-(+)-乳酸 溶液, 30% in H2O (by weight)
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 mL
请联系客服了解存货情况
¥959.53
250 mL
请联系客服了解存货情况
¥1,589.82
1 L
预计发货时间 2025年3月03日
详情...
¥4,333.27
Sigma-Aldrich
L-(+)-乳酸, 80%
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 L
预计发货时间 2025年3月03日
详情...
¥485.43
Sigma-Aldrich
L-(+)-乳酸 溶液, ~40% in H2O
登录查看公司和协议定价
货号包装规格是否有货价格数量
250 mL
请联系客服了解存货情况
¥1,918.68
1 L
请联系客服了解存货情况
¥5,682.23
Sigma-Aldrich
L-(+)-乳酸 溶液, meets analytical specification of Ph. Eur., BP, 88-92% total acid basis
登录查看公司和协议定价
货号包装规格是否有货价格数量
500 mL
预计发货时间 2025年3月03日
详情...
¥1,118.36
1 L
请联系客服了解存货情况
¥2,124.76
2.5 L
预计发货时间 2025年7月04日
详情...
¥3,814.18
25 kg
预计发货时间 2025年5月22日
详情...
¥5,297.33
Sigma-Aldrich
L-(+)-乳酸, Vetec, reagent grade, 86%
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 g
请联系客服了解存货情况
¥291.25
500 g
预计发货时间 2025年3月03日
详情...
¥469.38