- Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides.
Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides.
Chemical communications (Cambridge, England) (2011-11-16)
Ashish Thakur, Kainan Zhang, Janis Louie
PMID22083103
摘要
A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.
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