Ir(I)-catalyzed synthesis of N-substituted pyridones from 2-alkoxypyridines via C-O bond cleavage.

Ir(I)-catalyzed synthesis of N-substituted pyridones from 2-alkoxypyridines via C-O bond cleavage.

Organic letters (2013-04-02)

Shiguang Pan, Naoto Ryu, Takanori Shibata

摘要

A cationic Ir(I) complex-catalyzed O-to-N-alkyl migration in 2-alkoxypyridines bearing a secondary alkyl group on the oxygen atom by C-O bond cleavage is described. The present transformation gave various N-alkylpyridones in moderate to good yields. The addition of sodium acetate played a key role in suppressing β-hydrogen elimination.

材料

货号

品牌

产品描述

209686

Sigma-Aldrich

铱, powder, 99.9% trace metals basis

357324

Sigma-Aldrich

铱, foil, thickness 0.25 mm, 99.9% trace metals basis

449229

Sigma-Aldrich

铱, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.9% trace metals basis