Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.

Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.

Organic letters (2000-09-29)

R M Garbaccio, S J Danishefsky

摘要

A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide.