- A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones.
A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones.
Chemical communications (Cambridge, England) (2012-06-28)
Pei Chui Too, Shunsuke Chiba
PMID22735269
摘要
A method for synthesis of 4-bromoisoquinolones has been developed starting from 2-alkynylbenzaldehydes and primary amines mediated by CuBr under an O(2) atmosphere, where CuBr plays multiple roles to facilitate the present reactions.