Fluorinase mediated chemoenzymatic synthesis of [(18)F]-fluoroacetate.

Fluorinase mediated chemoenzymatic synthesis of [(18)F]-fluoroacetate.

Chemical communications (Cambridge, England) (2010-09-21)

Xiang-Guo Li, Juozas Domarkas, David O'Hagan

PMID20852791

摘要

A novel preparation of sodium [(18)F]-fluoroacetate is described where 5'-[(18)F]-fluoro-5'-deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-l-methionine (SAM) with no carrier added [(18)F]-fluoride and then oxidation to [(18)F]-fluoroacetate by a Kuhn-Roth oxidative degradation.