IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.

IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.

Bioscience, biotechnology, and biochemistry (2010-09-14)

Saya Kawahara, Ipei Iwata, Eriko Fujita, Manami Yamawaki, Hisashi Nishiwaki, Takuya Sugahara, Satoshi Yamauchi, Koichi Akiyama, Taro Kishida

PMID20834158

摘要

The IgE-suppressive activity of (-)-matairesinol is demonstrated, and the structure-activity relationship of (-)-matairesinol clarified. 3',4-Dihydroxy-3,4'-dimethoxylignano-9,9'-lactone showed higher IgE-suppressive activity than (-)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.