Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists.

Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists.

Bioorganic & medicinal chemistry letters (2005-12-21)

Romano Di Fabio, Riccardo Giovannini, Barbara Bertani, Manuela Borriello, Andrea Bozzoli, Daniele Donati, Alessandro Falchi, Damiano Ghirlanda, Colin P Leslie, Angelo Pecunioso, Giovanna Rumboldt, Simone Spada

PMID16364642

摘要

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat.