跳转至内容

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

We are planning system maintenance between Friday, Apr 11 at 9:00 PM CDT and Saturday, Apr 12 at 9:00 AM CDT. This will impact both web and offline transactions, including online orders, quotes, price and availability checks, and order status inquiries. We apologize for any inconvenience.

Merck
CN
  • Paxillin regulates Rab5-mediated vesicle motility through modulating microtubule acetylation.

Paxillin regulates Rab5-mediated vesicle motility through modulating microtubule acetylation.

Molecular biology of the cell (2023-04-13)
Nicholas M Zehrbach, Fatemeh Dubois, Christopher E Turner
摘要

Rab GTPase-mediated vesicle trafficking of cell surface proteins, including integrins, through endocytic and recycling pathways is important in controlling cell-extracellular matrix interactions during cell migration. The focal adhesion adaptor protein, paxillin, plays a central role in regulating adhesion dynamics and was previously shown to promote anterograde vesicle trafficking through modulation of microtubule acetylation via its inhibition of the deacetylase HDAC6. The role of paxillin in retrograde trafficking is unknown. Herein, we identified a role for paxillin in the modulation of the Rab5 GTPase, which is necessary for regulating early endosome dynamics and focal adhesion turnover. Using MDA-MB-231 breast cancer cells and paxillin (-/-) fibroblasts, paxillin was shown to impact Rab5-associated vesicle size and distribution, as well as Rab5 GTPase activity, through its modulation of HDAC6. Using a combination of real-time imaging and particle tracking analysis, paxillin was shown to promote Rab5-associated vesicle motility through inhibition of HDAC6-mediated micro-tubule deacetylation, along with the localization of active integrin to focal adhesions.

材料
货号
品牌
产品描述

Roche
不含EDTA的cOmplete Mini蛋白酶抑制剂混合物, Tablets provided in EASYpacks
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 g
请联系客服了解存货情况
¥3,866.86
1 kg
请联系客服了解存货情况
¥15,933.00
25 kg
请联系客服了解存货情况
¥176,011.06
Sigma-Aldrich
Dynarrestin, ≥98% (HPLC)
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 g
请联系客服了解存货情况
¥3,866.86
1 kg
请联系客服了解存货情况
¥15,933.00
25 kg
请联系客服了解存货情况
¥176,011.06