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Merck
CN
  • Small molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen.

Small molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen.

Chemical biology & drug design (2011-12-08)
Charles Rubert Pérez, Daneli López-Pérez, Jean Chmielewski, Mark Lipton
摘要

Two molecular scaffolds were designed using the CAVEAT molecular design package to inhibit the oligomerization of protective antigen (PA(63) ), a key protein component of anthrax toxin. The inhibitors were designed to prevent heptamerization of PA(63) by mimicking key residues of PA(63) needed for the intermolecular interactions that stabilize the heptamer. Using the scaffolds identified by CAVEAT, seven candidate inhibitors were synthesized and tested for their ability to inhibit anthrax toxin-induced cytotoxicity, with three of the agents demonstrating modest inhibition in murine J774A.1 macrophage cells.

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Supelco
Hexanes, 98.5% ACS, ~64% n-Hexane, Meets ACS Specifications