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  • MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1.

MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1.

Cancers (2022-02-26)
Jhen-Hao Jhan, Wei-Chi Hsu, Yi-Chen Lee, Wei-Ming Li, A-Mei Huang, Hui-Hui Lin, Chien-Sheng Wang, Yi-Ru Wu, Ching-Chia Li, Wen-Jeng Wu, Hung-Lung Ke
摘要

Little is known regarding the molecular characterization of upper tract urothelial carcinoma (UTUC). Novel therapeutic targets and prognostic predictors are imminent. In the present study, we aim to examine the oncogenic function and molecular mechanism of Derlin-1 in UTUC. Derlin-1 overexpression is significantly associated with poor prognosis in patients with UTUC. In vitro, knockdown or over-expression of Derlin-1 markedly regulated UTUC cell invasion and migration. We further discovered miR-375-3p suppresses cell invasion and migration by inversely regulating Derlin-1 and blocking EMT in UTUC cells. Taking this together, miR-375-3p functions as a tumor suppressive microRNA by directly targeting Derlin-1 and blocking epithelial-mesenchymal transition (EMT) in UTUC.

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Sigma-Aldrich
Anti-DERL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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货号包装规格是否有货价格数量
100 mg
预计发货时间 2025年3月03日
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¥2,543.42
500 mg
预计发货时间 2025年4月10日
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¥7,275.96
Sigma-Aldrich
Anti-OCLN Mouse mAb (1G7), liquid, clone 1G7, Calbiochem®
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 mg
预计发货时间 2025年3月03日
详情...
¥2,543.42
500 mg
预计发货时间 2025年4月10日
详情...
新价格,新优惠!
¥7,275.96