- Structure-activity relationship studies of curcumin analogues.
Structure-activity relationship studies of curcumin analogues.
Bioorganic & medicinal chemistry letters (2009-03-03)
James R Fuchs, Bulbul Pandit, Deepak Bhasin, Jonathan P Etter, Nicholas Regan, Dalia Abdelhamid, Chenglong Li, Jiayuh Lin, Pui-Kai Li
PMID19249204
摘要
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.
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