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Merck
CN
  • Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy.

Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy.

JACC. Basic to translational science (2019-11-12)
Toshiyuki Ko, Kanna Fujita, Seitaro Nomura, Yukari Uemura, Shintaro Yamada, Takashige Tobita, Manami Katoh, Masahiro Satoh, Masamichi Ito, Yukako Domoto, Yumiko Hosoya, Eisuke Amiya, Masaru Hatano, Hiroyuki Morita, Masashi Fukayama, Hiroyuki Aburatani, Issei Komuro
PMID31709317
摘要

This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X-positive nuclei in biopsy specimens compared with those without LVRR. Propensity analysis showed that the proportion of both PAR-positive and γ-H2A.X-positive nuclei were independent prognostic factors for LVRR. In conclusion, we showed the utility of DNA damage-marker staining to predict the probability of LVRR, thus revealing a novel prognostic predictor of medical therapy for dilated cardiomyopathy.