Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

Nature (1985-08-22)

R Derynck, J A Jarrett, E Y Chen, D H Eaton, J R Bell, R K Assoian, A B Roberts, M B Sporn, D V Goeddel

PMID3861940

摘要

The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.