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  • Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity.

Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity.

Biology open (2015-10-23)
Lama Tarayrah, Yuping Li, Qiang Gan, Xin Chen
摘要

Signaling pathways and epigenetic mechanisms have both been shown to play essential roles in regulating stem cell activity. While the role of either mechanism in this regulation is well established in multiple stem cell lineages, how the two mechanisms interact to regulate stem cell activity is not as well understood. Here we report that in the Drosophila testis, an H3K4me3-specific histone demethylase encoded by little imaginal discs (lid) maintains germline stem cell (GSC) mitotic index and prevents GSC premature differentiation. Lid is required in germ cells for proper expression of the Stat92E transcription factor, the downstream effector of the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling pathway. Our findings support a germ cell autonomous role for the JAK-STAT pathway in maintaining GSCs and place Lid as an upstream regulator of this pathway. Our study provides new insights into the biological functions of a histone demethylase in vivo and sheds light on the interaction between epigenetic mechanisms and signaling pathways in regulating stem cell activities.

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抗磷酸组蛋白H3(Thr3)抗体,克隆JY325,兔单克隆, clone JY325, from rabbit
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