P5806
Pasteurella multocida toxin
lyophilized powder
别名:
PMT
产品名称
Pasteurella multocida toxin, lyophilized powder
sterility
sterile-filtered
form
lyophilized powder
packaging
vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro. PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway. Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage
Pullinger GD, et al.
Molecular Microbiology, 51(1), 255-269 (2004)
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation
Harmey D, et al.
Journal of Bone and Mineral Research, 19(4), 661-670 (2004)
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and-independent mechanisms involvement of Gq but not G11
Zywietz A, et al.
The Journal of biological chemistry, 276(6) (2001)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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