N9653
纺锤霉素 二盐酸盐
From Streptomyces netropsis, ≥98% (HPLC), powder
别名:
Congocidin, Sinanomycin
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关于此项目
经验公式（希尔记法）:
C18H26N10O3 · 2HCl
化学文摘社编号:
分子量:
503.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
纺锤霉素 二盐酸盐, from Streptomyces netropsis, ≥98% (HPLC), powder
biological source
Streptomyces netropsis
Quality Level
assay
≥98% (HPLC)
form
powder
color
faintly yellow
solubility
H2O: 1 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, viruses
mode of action
DNA synthesis | interferes
storage temp.
−20°C
SMILES string
[H]Cl.[H]Cl.NC(CCNC(C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2C)=O)=CN1C)=O)=N
InChI
1S/C18H26N10O3.2ClH/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22;;/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24);2*1H
InChI key
SDRHUASONSRLFR-UHFFFAOYSA-N
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
Disclaimer
Protect from light.
存储类别
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Edwin A Lewis et al.
Nucleic acids research, 39(22), 9649-9658 (2011-09-06)
Structural results with minor groove binding agents, such as netropsin, have provided detailed, atomic level views of DNA molecular recognition. Solution studies, however, indicate that there is complexity in the binding of minor groove agents to a single site. Netropsin
M Poot et al.
Cell structure and function, 15(3), 151-157 (1990-06-01)
Distamycin A, netropsin and berenil are known to cause undercondensation of heterochromatic regions of metaphase chromosomes. These ligands interfere with DNA curvature by binding to the minor groove of the DNA. Whereas the effects of these ligands upon chromatin structure
Irina Belozerova et al.
Journal of the American Chemical Society, 134(45), 18667-18676 (2012-10-11)
A variety of solution methods exist for analysis of interactions between small molecule ligands and nucleic acids; however, accomplishing this task economically at the scale of hundreds to thousands of sequences remains challenging. Surface assays offer a prospective solution through
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N9653-5MG | 04061834118886 |