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L9793

LP44

Name: LP44
Brand: SIGMA

≥98% (HPLC), solid

别名:

4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₇H₃₈ClN₃OS

化学文摘社编号:

824958-12-5

分子量:

488.13

NACRES:

NA.77

PubChem Substance ID:

329817675

UNSPSC Code:

12352200

MDL number:

MFCD09971090

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: ≥2 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2

InChI

1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H

InChI key

DWGKCWWWKHCVDH-UHFFFAOYSA-N

说明

Application

LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.

Biochem/physiol Actions

LP44 is a high affinity 5-HT₇ receptor agonist.

LP44 is a high affinity 5-HT₇ receptor agonist. K_i = 0.22 nM. LP44 displays selectivity over 5-HT_1A and 5-HT_2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC₅₀ = 2.56 μM).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Prior work using a contractility bioassay determined that the serotonin (5-HT) receptor subtype 5-HT2A is present in bovine lateral saphenous veins and plays a role in ergot alkaloid (EA)-induced vascular contraction in steers grazing endophyte-infected (Epichloë coenophiala) tall fescue (Lolium

The serotonin (5-hydroxytryptamine) 5-HT7 receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury.

Jianshu Ni et al.

BJU international, 123(4), 718-725 (2018-05-22)

To examine the effect of intrathecal (i.t.) serotonin (5-hydroxytryptamine) 5-HT7 agonist administration on voiding function in the urethane-anesthetised rat, and the change in 5-HT7 receptor (5-HT7 R) expression in the lumbosacral cord Onuf's nucleus after spinal cord injury (SCI). In

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This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular methods. This study was conducted in two steps. For in vivo studies, 24 female

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全球贸易项目编号

货号	GTIN
L9793-10MG	04061832072159
L9793-50MG	04061832072166