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Merck
CN
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安全信息

HPA001893

Sigma-Aldrich

抗-SIX1 兔抗

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-Sine oculis同源框同源物1 兔抗, 抗-同源框蛋白SIX1 兔抗

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选择尺寸

100 μL
CN¥5,074.24

CN¥5,074.24

国内现货，预计发货时间April 10, 2025详情

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100 μL
CN¥5,074.24

About This Item

UNSPSC代码:
12352203
人类蛋白质图谱编号:
HPA001893
NACRES:
NA.41

CN¥5,074.24

国内现货，预计发货时间April 10, 2025详情

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

表单

buffered aqueous glycerol solution

种属反应性

human

增强验证

RNAi knockdown
recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技术

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

相关类别

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Anti-SGCG antibody produced in rabbit Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

免疫原

同源框蛋白SIX1重组蛋白表位标记标签（PrEST）

应用

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证，因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分： 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证，并且通过近期人类细胞图谱项目的努力，许多抗体已经过免疫荧光分析的表征，从而绘制人类蛋白质组图谱，不仅是在组织水平上，现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接，可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。

生化/生理作用

Sine oculis同源框同源物（SIX1）介导细胞凋亡和自噬，并调节对肝细胞癌药物的耐药性。它在结肠直肠癌中高度表达，并促进肿瘤进展。SIX1的异常表达与霍奇金淋巴瘤和乳腺癌有关。

特点和优势

Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的：
  • 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
  • 364个人类重组蛋白片段的蛋白阵列。

联系

相应抗原APREST70399

外形

溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    C75776
    C35230
    B40182
    B40173
    B38818

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    Wai Jin Tan et al.
    Histopathology, 64(6), 807-817 (2014-01-21)
    Homeoproteins are transcription factors which critically regulate developmental processes. Deregulated expression of homeoproteins is observed in several malignancies, such as breast cancer and rhabdomyosarcoma, and contributes to malignant progression. We aimed to investigate the expression and prognostic importance of Six1
    Jenny Wegert et al.
    Cancer cell, 27(2), 298-311 (2015-02-12)
    Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find therapeutic leads for this subgroup, we analyzed 58 blastemal type Wilms tumors by exome and transcriptome sequencing and validated
    Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer.
    Kahlert C, et al.
    International Journal of Cancer. Journal International Du Cancer, 137(9), 2104-2113 (2015)
    Daniela Roellig et al.
    eLife, 6 (2017-03-30)
    The 'neural plate border' of vertebrate embryos contains precursors of neural crest and placode cells, both defining vertebrate characteristics. How these lineages segregate from neural and epidermal fates has been a matter of debate. We address this by performing a
    Shu-Hua Sun et al.
    Oncology letters, 12(2), 1271-1278 (2016-07-23)
    Epithelial-mesenchymal transition (EMT) plays a critical role in promoting tumor invasion and metastasis. However, the key cofactors that modulate the signal transduction to induce EMT have note been fully explored to date. The present study reports that sine oculis homeobox
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