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F5135

N-[3-(2-呋喃基)丙烯酰基]-亮氨酸-甘氨酸-脯氨酸-丙氨酸

collagenase substrate, chromogenic

别名:

FALGPA, N-[3-(2-呋喃基)丙烯酰基]-L-亮氨酸-甘氨酸-L-脯氨酸-L-丙氨酸

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关于此项目

经验公式（希尔记法）:
C23H32N4O7
化学文摘社编号:
78832-65-2
分子量:
476.52
UNSPSC Code:
12352202
PubChem Substance ID:
329799652
NACRES:
NA.32
MDL number:
MFCD00133552
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产品名称

N-[3-(2-呋喃基)丙烯酰基]-亮氨酸-甘氨酸-脯氨酸-丙氨酸,

Quality Level

200

UniProt accession no.

Q02111

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)\C=C\c1ccco1)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(O)=O

InChI

1S/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

InChI key

ZLFQNOJSYZSINX-PVJKAEHXSA-N

Gene Information

mouse ... Prkcq(18761)

General description

N-[3-(2-呋喃基)丙烯酰基]-亮氨酸-甘氨酸-脯氨酸-丙氨酸或FALGPA是一种类似于胶原蛋白一级结构的合成物质，可以被所有已知的胶原酶水解。
胶原酶的底物。

Application

N-[3-(2-呋喃基)丙烯酰基]-亮氨酸-甘氨酸-脯氨酸-丙氨酸已用于采用GBS（B组链球菌）USF704进行的FALGPA检测。

Biochem/physiol Actions

N-[3-(2-呋喃基)丙烯酰基]-亮氨酸-甘氨酸-脯氨酸-丙氨酸或FALGPA可以被胶原酶水解，水解的最适pH为7.4。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP3919
BCCM1118
BCCK4776
BCCH9650
BCCG5673

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实验方案

Enzymatic Assay of Collagenase (EC 3.4.24.3) using FALGPA (N-(3-[2-Furyl]acryloyl)-Leu-Gly-Pro-Ala)

To measure collagenase activity, N-(3-[2-Furyl]acryloyl)-Leu-Gly-Pro-Ala is used in a continuous spectrophotometric rate determination at 345 nm. Collagenase hydrolyzes collagen peptide bonds.

使用FALGPA（N-（3- [2-呋喃基]丙烯酰基）-Leu-Gly-Pro-Ala）进行的胶原酶酶法检测（EC 3.4.24.3）

在测定胶原酶活性时，使用N-（3-[2-呋喃基]丙烯酰基）-Leu-Gly-Pro-Ala在345nm处进行连续分光光度法测定。胶原酶水解胶原肽键。

K K Mäkinen et al.
The Journal of biological chemistry, 267(20), 14285-14293 (1992-07-15)
An endopeptidase was purified to homogeneity from the cell extracts of Treponema denticola ATCC 35405 (a human oral spirochete) by a procedure that comprised dialysis, anion exchange fast protein liquid chromatography (FPLC), hydroxylapatite FPLC, immobilized metal affinity FPLC, FPLC chromatofocusing
B Lin et al.
Infection and immunity, 64(8), 3401-3406 (1996-08-01)
Group B streptococci were recently reported to possess a cell-associated collagenase. Although the enzyme hydrolyzed the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly-Pro-Ala, we found that neither the highly purified enzyme nor crude group B streptococcal cell lysate solubilized a film of reconstituted
Z E Juarez et al.
Infection and immunity, 67(1), 271-278 (1998-12-24)
Streptococcus gordonii is a frequent cause of infective bacterial endocarditis, but its mechanisms of virulence are not well defined. In this study, streptococcal proteases were recovered from spent chemically defined medium (CDM) and fractionated by ammonium sulfate precipitation and by
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