重组
expressed in E. coli
方案
≥95% (SDS-PAGE)
表单
buffered aqueous solution
比活
≥1,500 units/mg protein
分子量
56 kDa by immunoblotting
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CASP7(840)
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此商品 | 466190 | T1199 | 45979 |
|---|---|---|---|
| assay ≥99.5% (GC) | assay 98% | assay - | assay - |
| solubility H2O: slightly soluble | solubility H2O: slightly soluble | solubility - | solubility H2O: slightly soluble |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form liquid | form liquid | form - | form - |
| mp −28 °C (lit.) | mp −28 °C (lit.) | mp - | mp −28 °C (lit.) |
| density 1.008 g/mL at 25 °C (lit.) | density 1.008 g/mL at 25 °C (lit.) | density - | density 1.008 g/mL at 25 °C (lit.) |
生化/生理作用
Cleaves the substrates consisting of consensus sequence DEVD.
Member of the CED-3 subfamily, the effector caspases, with an essential role in the apoptotic process. Upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions. It is responsible for the cleavage of cellular substrates that precipitate the morphological changes of apoptosis.
Member of the CED-3 subfamily, the effector caspases; upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions.
Useful in screening caspase inhibitors, studying enzyme regulation, determining specificities of caspase substrates, as well as using as a positive control in caspase activity assays and Western blot analyses.
单位定义
One unit will hydrolyze 1.0 nmol of Ac-Asp-Glu-Val-Asp-AFC per minute at pH 7.5 at 25 °C.
外形
Solution in HEPES, NaCl, DTT and sucrose, without carrier protein
分析说明
Migrates as two major polypeptides (20 kDa and 10 kDa) in immunoblotting. Two minor polypeptides derived from the large subunit are also present.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
J M Chandler et al.
The Journal of biological chemistry, 273(18), 10815-10818 (1998-06-06)
Caspases plays a key role in the execution phase of apoptosis. "Initiator" caspases, such as caspase-8, activate "effector" caspases, such as caspase-3 and -7, which subsequently cleave cellular substrates thereby precipitating the dramatic morphological changes of apoptosis. Following treatment of
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