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安全信息

B5507

Sigma-Aldrich

硫酸博来霉素 来源于轮枝链霉菌

crystalline, 1.5-2.0 U/mg

别名:

Blenoxane, Bleo, Blexane

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1 G
CN¥1,399.61

CN¥1,399.61

预计发货时间June 26, 2025详情

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1 G
CN¥1,399.61

About This Item

CAS号:
9041-93-4
EC 号:
232-925-2
MDL编号:
MFCD00070310
UNSPSC代码:
12352200
PubChem化学物质编号:
24891839
NACRES:
NA.77

CN¥1,399.61

预计发货时间June 26, 2025详情

获取大包装报价

表单

crystalline

质量水平

200

比活

1.5-2.0 U/mg

颜色

white to off-white

溶解性

H2O: 20 mg/mL

痕量阳离子

Cu: ≤0.10%

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES字符串

[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C

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此商品
224227342254204757
氧化钌(IV) 99.9% trace metals basis

238058

氧化钌(IV)

钛 (IV) 氧化物，金红石型 powder, <5 μm, ≥99.9% trace metals basis

224227

钛 (IV) 氧化物，金红石型

氧化铼(IV) 99.7% trace metals basis

342254

氧化铼(IV)

钛 (IV) 氧化物，金红石型 ≥99.98% trace metals basis

204757

钛 (IV) 氧化物，金红石型

assay

99.9% trace metals basis

assay

≥99.9% trace metals basis

assay

99.7% trace metals basis

assay

≥99.98% trace metals basis

form

powder and chunks

form

powder

form

powder

form

powder

density

6.97 g/mL at 25 °C (lit.)

density

4.17 g/mL at 25 °C (lit.)

density

-

density

4.17 g/mL at 25 °C (lit.)

reaction suitability

reagent type: catalyst
core: ruthenium

reaction suitability

reagent type: catalyst
core: titanium

reaction suitability

reagent type: catalyst
core: rhenium

reaction suitability

reagent type: catalyst
core: titanium

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

一般描述

Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus.[1] It is recommended for use as a cell culture agent at 10-100 μg/mL.
Chemical structure: glycopeptide

应用

Bleomycin Sulfate is an atineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Bleomycin sulfate from Streptomyces verticillus has been used:
  • to study the impact of telomere shortening in lung fibrosis[2]
  • to induce lung injury and study its effect on CEACAM6 expression[3]
  • as a DNA-alkylating agent to induce lung injury
  • study its effect on CEACAM6 expression [4]
  • to cause lung injury
  • subsequent fibrosis in animals[5]

生化/生理作用

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

组分

This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.

注意

This product should be stored at 2-8°C.

制备说明

The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.

其他说明

Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H351,H361fd

危险分类

Carc. 2 - Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000415087
0000415087
0000286581
0000269493
0000286581

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Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice
Lin S, et al.
Physiological Reports, 3(12), e12657-e12657 (2015)
Telomere shortening activates TGF-betaSmads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis
Liu YY, et al.
Acta Pharmacologica Sinica, 39(11), 1735-1735 (2018)
Loss of CDKN2B promotes fibrosis via increased fibroblast differentiation rather than proliferation
Scruggs AM, et al.
American Journal of Respiratory Cell and Molecular Biology, 59(2), 200-214 (2018)
Assembly of the Elongin A ubiquitin ligase is regulated by genotoxic and other stresses
Weems JC, et al.
The Journal of Biological Chemistry, 290(24), 15030-15041 (2015)
Carcinogenicity of bleomycin sulfate and peplomycin sulfate after repeated subcutaneous application to rats
Habs M and Schmahl D
Oncology, 41(2), 114-119 (1984)
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